CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.
نویسندگان
چکیده
The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8+ T lymphocytes may be inversely associated with viral load suggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8+ T lymphocytes, which is distinct from that activity elicited by some cytolytic CD8+ T lymphocytes (CTLs).
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ورودعنوان ژورنال:
- Frontiers in bioscience : a journal and virtual library
دوره 6 شماره
صفحات -
تاریخ انتشار 2001